| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284322 | Neuroscience Letters | 2012 | 6 Pages |
Abstract
⺠We explore if estrogen protects cells from Aβ42 toxicity by inhibiting ASK1 or modulating Trx1. ⺠We examine estrogen effects on AKT and ERK pathways as wells as on ASK1 and Trx1. ⺠We explore the contribution of estrogen receptors by using agonists against αor β. ⺠Estrogen's protection against Aβ42 occurs via ERα, AKT, and the inhibition of ASK1. ⺠The protective mechanisms are independent of Trx1.
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Authors
Laura Mateos, Torbjörn Persson, Shirin Kathozi, Francisco Javier Gil-Bea, Angel Cedazo-Minguez,