| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284324 | Neuroscience Letters | 2012 | 5 Pages |
Abstract
⺠Polyamine derivative, BsHSPMG inhibited strongly NMDA receptor currents. ⺠BsHSPMG acts deeply into the channel pore of NMDA receptors containing the intracellular regions. ⺠Cellular toxicity of BsHSPMG was approximately 2-fold weaker than that of TsHSPMG, and 40-fold weaker than that of memantine. ⺠Administration of BsHSPMG exhibited neuroprotective effect on mouse brain ischemia.
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Authors
Takashi Masuko, Toyofumi Suzuki, Muneharu Miyake, Kuniko Kusama-Eguchi, Yasuo Kizawa, Kazuo Tomono, Keiko Kashiwagi, Kazuei Igarashi, Tadashi Kusama,