| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284364 | Neuroscience Letters | 2012 | 4 Pages |
Abstract
⺠Investigating the site of action of flupirtine within the rat brain. ⺠Nerve terminals of trigeminal first-order neurons project within the brainstem. ⺠These nerve terminals release CGRP at the brainstem level. ⺠Flupirtine inhibits CGRP release from isolated rat brainstems. ⺠Evidence that CGRP release is inhibited by flupirtine via modulation of Kv7 channels.
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Authors
Giuseppe Tringali, Maria Cristina Greco, Alessandro Capuano, Giuseppe Guerriero, Diego Currò, Pierluigi Navarra,