Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6284386 | Neuroscience Letters | 2011 | 6 Pages |
Abstract
⺠Consequences of NOS-knockout on neuronal precursors in the SGZ and SVZ were analyzed. ⺠Neonatal, adult and 18-month-old wild-type, nNOS-, eNOS-, and iNOS-minus mice were studied. ⺠Reduced NO supply, initially inducing cell proliferation in nNOS-minus mice, leads to exhausted cell division in age. ⺠Present study supports the idea of a finite proliferation capacity of neuronal stem cells.
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Authors
Gerburg Keilhoff,