| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284392 | Neuroscience Letters | 2011 | 5 Pages |
Abstract
⺠Cytochrome c is depleted and p53 level is elevated in chronic Parkinson's mice. ⺠Long-term exercise prevents cytochrome c release and p53 elevation. ⺠TFAM and PGC-1α transcriptional activities are upregulated in Parkinson's mice. ⺠Long-term exercise brings TFAM and PGC-1α levels down closer to normal ranges. ⺠Exercise reduces mitochondrial damage and prevents neurodegenerative process.
Keywords
p53TFAMmPDGAPDHPGC-1αMPTP1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineMitochondrial DNAROSSNpcParkinson's diseaseanalysis of varianceANOVAsubstantia nigra pars compactaNeurodegenerationDopaminemtDNAcytochrome cmitochondrial transcription factor ATreadmill exerciseperoxisome proliferator-activated receptor gamma coactivator 1αglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen species
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Authors
Gaurav Patki, Yuen-Sum Lau,