Caspase-3 is a target gene of c-Jun:ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons

Article ID	Journal	Published Year	Pages	File Type
6284481	Neuroscience Letters	2011	6 Pages	PDF

Abstract

âº Caspase-3 is up-regulated during apoptosis induced by activity deprivation in CGNs. âº Caspase-3 is a target gene of the JNK/c-Jun:ATF2 pathway. âº c-Jun:ATF2 heterodimers bind directly to the ATF site of the caspase-3 promoter in vivo.

Keywords

Jnk c-Jun NH2-terminal kinase ATF2 CGN DMSO MOI Quantitative PCR q-PCR chromatin immunoprecipitation c-Jun Apoptosis DIV Dimethylsulfoxide days in vitro Transcription Neuron cerebellar granule neuron multiplicity of infection CHiP Caspase-3