Intranasal inoculation with an adenovirus vaccine encoding ten repeats of Aβ3-10 induces Th2 immune response against amyloid-β in wild-type mouse

► We constructed a novel adenovirus vaccine Ad-10 × Aβ3-10-CpG. ► Ad-10 × Aβ3-10-CpG induced high titers of anti-Aβ antibodies. ► The anti-Aβ antibodies are immunoreactive to Aβ plaque in AD mouse model. ► Ad-10 × Aβ3-10-CpG induced a Th2-polarized immune response. ► Ad-10 × Aβ3-10-CpG could avoid T cell-mediated autoimmune response.