| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284511 | Neuroscience Letters | 2011 | 6 Pages |
Abstract
⺠Positive allosteric modulation of mGluR5 protects neurons from FG-mediated toxicity. ⺠MGluR5 modulation down-regulates FG-mediated microglia activation. ⺠Microglia are essential for mediating the neuroprotective effect.
Keywords
PFAPMX(2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl)glycineNDDSLMECDPPBMTEPmGluR5NAAGmGluRTNFαiNOSLPSFBSSTSERK1/2CGCextracellular signal-regulated kinase1/2N-acetylaspartylglutamateNeurodegenerative disordersstaurosporinetumour necrosis factor-αCNSBBBblood brain barrierfoetal bovine serumcerebellar granule cellsNeurotoxicityinducible nitric oxide synthasecentral nervous systemFibrinogenlactate dehydrogenaseLDHlipopolysaccharideMEMMicrogliaparaformaldehydePropidium iodidepolymyxin BMetabotropic glutamate receptor
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Authors
Thomas M. Piers, Simon J. Heales, Jennifer M. Pocock,