Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve

► We studied changes of IL-10 protein in dorsal root ganglia after nerve constriction injury. ► IL-10 protein was examined by immunohistochemistry and ELISA in dorsal root ganglia of spinal cord levels homo- and heteronymous to injured nerve. ► Transient bilateral elevation of IL-10 protein occurred in the homo- and heteronymous ganglia. ► Bilateral elevation of IL-10 in dorsal root ganglia was also observed after sham operations.