Impaired long-trace eyeblink conditioning in a Tg2576 mouse model of Alzheimer's disease

Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI = 500 ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (106 K)Download as PowerPoint slideHighlights► Our longitudinal study examined eyeblink conditioning in a Tg2576 mouse model of AD. ► Long-trace eyeblink conditioning was severely impaired in Tg2576 mice aged 6 months. ► Delay eyeblink conditioning was not impaired in Tg2576 mice even at 12 months of age. ► The trace conditioning is susceptible to AD-related cognitive decline in mouse model.