Sustained acceleration of colonic transit following chronic homotypic stress in oxytocin knockout mice

Article ID	Journal	Published Year	Pages	File Type
6284679	Neuroscience Letters	2011	5 Pages	PDF

Abstract

âº Acute stress significantly accelerated colonic transit in WT and OXT-KO mice. âº Accelerated colonic transit was attenuated in WT mice following chronic stress. âº The colonic transit was still accelerated in OXT-KO mice following chronic stress. âº CRF was upregulated in OXT-KO and downregulated in WT mice after chronic stress.

Keywords

IBS CRF Hypothalamus–pituitary–adrenal (HPA) axis Acute stress Gastrointestinal irritable bowel syndrome corticotropin releasing factor SON PVN hypothalamus–pituitary–adrenal axis HPA wild type Supraoptic nucleus paraventricular nucleus corticotropin releasing hormone