Article ID Journal Published Year Pages File Type
6284760 Neuroscience Letters 2011 5 Pages PDF
Abstract
► Effects of reproductive experience on amphetamine sensitization were tested. ► Primiparous and nulliparous female rats were treated with 0, 1, or 5 mg/kg amphetamine for 5 days. ► Animals were treated with amphetamine (1 or 5 mg/kg) or saline for 5 consecutive days. ► All animals were challenged with low-dose amphetamine after 10 days of withdrawal. ► High-dose amphetamine treatment increased response to challenge in primiparous rats. ► Increased amphetamine sensitization may be a consequence of reproductive experience.
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