| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284768 | Neuroscience Letters | 2011 | 8 Pages |
Abstract
⺠Global levels of ubiquitinated proteins increased in the hippocampus of Tg2576 mice. ⺠No global changes in either SUMO-1 or SUMO-2/3 conjugation in any brain regions analysed. ⺠SUMO conjugating and deconjugating enzymes, UBC9 and SENP-1, unaltered in Tg2576 mice. ⺠Total levels of AMPA and kainate receptors were also unaffected in Tg2576 mice. ⺠Posttranslational modification by ubiquitin may play a role in Alzheimer's disease.
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Authors
Laura E. McMillan, Jon T. Brown, Jeremy M. Henley, Helena Cimarosti,