P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes

Article ID	Journal	Published Year	Pages	File Type
6284814	Neuroscience Letters	2011	5 Pages	PDF

Abstract

âº APP production and secretion is stimulated by extracellular ATP. âº ATP-stimulated APP production and secretion involves purinergic receptors. âº P2Y receptors mediate ATP-stimulated expression and secretion of APP. âº ATP-stimulated expression and secretion of APP involve protein kinase signaling.

Keywords

DMEM RB2 SB202190 NECA SP600125 PPADS 2MeSADP BzATP NGF APP DAPI PI3K ERK 4′-6-diamidino-2-phenylindole MAPK MAPK/ERK kinase Dulbecco's modified Eagle's medium SAPK/JNK reactive blue 2 Astrocytes stress-activated protein kinase/c-Jun N-terminal kinase Alzheimer's disease extracellular signal regulated protein kinase nerve growth factor Phosphatidylinositol 3-kinase MEK amyloid precursor protein Protein kinase mitogen-activated protein kinase purinergic receptor