Purified high molecular weight synthetic Aβ(1-42) and biological Aβ oligomers are equipotent in rapidly inducing MTT formazan exocytosis

► Purified soluble Aβ oligomers rapidly induce cellular MTT formazan exocytosis. ► Synthetic Aβ(1-42) and cell-derived oligomers equipotently stimulate exocytosis. ► Half-maximal stimulation of exocytosis induced by 10-20 nM oligomers. ► Monomeric Aβ attenuates the effect of soluble oligomers.