Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6284940 | Neuroscience Letters | 2011 | 5 Pages |
Abstract
â¶ The atypical opioid tramadol dose-dependently increased extracellular serotonin (5-HT) and noradrenaline (NA) levels in the ventral hippocampus of freely moving rats. â¶ The antidepressant drugs duloxetine, venlafaxine and clomipramine increased extracellular 5-HT and NA levels. â¶ Citalopram selectively increased extracellular 5-HT levels. â¶ Reboxetine increased extracellular NA levels and to a minimal degree 5-HT levels.â¶ The effects of tramadol on the 5-HT and NA levels resemble those of duloxetine, venlafaxine, and clomipramine, and differ from those of citalopram and reboxetine.
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Authors
P. Bloms-Funke, E. Dremencov, T.I.F.H. Cremers, T.M. Tzschentke,