| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284988 | Neuroscience Letters | 2010 | 5 Pages |
Abstract
ⶠBACE1 and γ-secretase sequentially cleave the sodium channel β2-subunit. ⶠSequential cleavage of the β2-subunit releases its intracellular domain. ⶠThe intracellular domain of the β2-subunit localizes into nucleus. ⶠβ2-subunit's intracellular domain regulates sodium channel α-subunit, Nav1.1 levels. ⶠElevated BACE1 activity dramatically decreases surface Nav1.1 levels in neuronal cells.
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Authors
Dora M. Kovacs, Manuel T. Gersbacher, Doo Yeon Kim,