Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6284995 | Neuroscience Letters | 2010 | 9 Pages |
Abstract
â¶ Votage-gated sodium (Nav) channels underlie the generation and propagation of action potential in neurons. â¶ Concentration of axonal Nav to the axon initial segment and nodes of Ranvier is critical for their function. â¶ This localization depends on protein-protein interactions and assembly of specialized supra-molecular complexes. â¶ Details about the targeting and trafficking of Nav to the AIS and nodes have recently been obtained, however a lot of questions remain.
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Authors
Christophe Leterrier, Anna Brachet, Marie-Pierre Fache, Bénédicte Dargent,