Voltage-gated sodium channel organization in neurons: Protein interactions and trafficking pathways

▶ Votage-gated sodium (Nav) channels underlie the generation and propagation of action potential in neurons. ▶ Concentration of axonal Nav to the axon initial segment and nodes of Ranvier is critical for their function. ▶ This localization depends on protein-protein interactions and assembly of specialized supra-molecular complexes. ▶ Details about the targeting and trafficking of Nav to the AIS and nodes have recently been obtained, however a lot of questions remain.