Treatment with olanzapine, fluoxetine and olanzapine/fluoxetine alters citrate synthase activity in rat brain

▶ Acute treatment with olanzapine and fluoxetine (alone) increased the citrate synthase activity in rat brain. Interestingly acute treatment with olanzapine 3 mg/kg and fluoxetine 12.5 mg/kg in combination increased citrate synthase activity in prefrontal cortex, hippocampus and striatum. ▶ Chronic treatment with olanzapine and fluoxetine alone or in combination did not alter the citrate synthase activity when the rats were killed 2 or 24 h after last administration. ▶ Our results indicate that the effects of the olanzapine and fluoxetine might involve mitochondrial function, but this effect is treatment regime-related in some rat brain areas.