An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis

▶ P-glycoprotein is a significant BBB-related efflux transporter protein associated with β-amyloid transport. ▶ This study demonstrates a significant negative correlation between P-gp positive capillary density and both NFT and SP lesions in AD, but not control, cortical brain samples. ▶ This study demonstrates a significant positive correlation between P-gp-positive capillaries and both LRP and Rage-positive capillaries in both AD and control cortical brain samples. ▶ We infer that these results suggest that the levels of capillary P-gp may contribute to AD lesion development and that the role of P-gp is associated with the roles of LRP and RAGE.