Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6286012 | Neuroscience Research | 2016 | 5 Pages |
Abstract
17β-Estradiol (E2) exerts neurotrophic and neuroprotective functions in the brain. Here, E2-induced increased levels of huntingtin (HTT), a protein involved in several crucial neuronal functions is reported. E2 physiological concentrations up-regulate HTT in hippocampus and striatum of rats as well as in human neuroblastoma cells. This effect requires both nuclear and extra-nuclear estrogen receptor (ER)α activities. Intriguingly, HTT silencing completely prevents E2 protective effects against oxidative stress injury. In conclusion, these data indicate for the first time that HTT is an E2-inducible protein involved in the first steps of E2-induced signaling pathways committed to neuronal protection against oxidative stress.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Maria Teresa Nuzzo, Marco Fiocchetti, Michela Servadio, Viviana Trezza, Paolo Ascenzi, Maria Marino,