Article ID Journal Published Year Pages File Type
6286234 Neuroscience Research 2014 4 Pages PDF
Abstract

•Cannabidiol promotes adenosine accumulation.•Microinjection of cannabidiol increases extracellular levels of adenosine.•Cannabidiol enhances sleep-inducing molecule.

Cannabidiol (CBD) is a constituent of Cannabis sativa that promotes wakefulness as well as enhances endogenous levels of wake-related neurotransmitters, including dopamine. However, at this date, the effects of CBD on the sleep-inducing molecules, such as adenosine (AD), are unknown. Here, we report that intrahypothalamic injection of CBD (10 μg/1 μL) increases the extracellular levels of AD collected from nucleus accumbens. Furthermore, the pharmacodynamic of this drug shows that effects on the contents of AD last 2 h post-injection. These preliminary findings suggest that CBD promotes the endogenous accumulation of AD.

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