Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6286392 | Neuroscience Research | 2013 | 21 Pages |
Abstract
To elucidate a relationship between changes in focal brain temperature and severity of abnormal brain activity, epileptiform discharges and behavioral seizures were induced by Penicillin G in anesthetized rats, and focal brain-temperature was measured. Penicillin G was injected into the right primary sensorimotor cortex (400 IU/μl). After the injection, epileptiform discharges induced a temperature increase gradually by 0.65 ± 0.24 °C. Moreover, when behavioral seizures were induced by reducing the anesthesia level, the temperature was raised by 0.26 ± 0.22 °C. These results suggest that elevation of the focal brain temperature is associated with the severity of epileptic activity.
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Authors
Tatsuji Tokiwa, Takao Inoue, Masami Fujii, Satoru Ishizuka, Shuji Aou, Hiroyuki Kida, Yuichi Maruta, Toshitaka Yamakawa, Sadahiro Nomura, Michiyasu Suzuki, Takeshi Yamakawa,