Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6286500 | Progress in Neurobiology | 2014 | 24 Pages |
Abstract
Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications.
Keywords
SDF-1tPAbFGFSVZCXCR4NSCsischemic boundary zoneBMSCsIBZIPSCsLGEMCAOGDNFangiopoietin-1MRSRMSMCP-1NGFIGF-1ESCschemokine (C-X-C motif) receptor 4GvHDNIHSSSPIONIRPlGFHGFUCMSCsGFPMSCshMSCsBDNFNeurorestorationNPCsAng-1Human leukocyte antigenHLASTEPSMRImiddle cerebral artery occlusionSuperparamagnetic iron oxidelateral ganglionic eminenceGraft-versus-host diseaseMagnetic resonance imaginggridrostral migratory streamIntra-arterialIntravenousCell-based therapiesintracerebralCNSBBBBlood–brain barrierbone marrow stromal cellsStem cellsMesenchymal stem cellshuman mesenchymal stem cellsUmbilical cord mesenchymal stem cellsInduced pluripotent stem cellsHuman umbilical cord blood cellsEmbryonic stem cellsNeural stem cellsNeural progenitor cellsIschemic strokecentral nervous systemplacental growth factorHepatocyte growth factorStromal-derived factor 1Vascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nerve growth factorbasic fibroblast growth factorinsulin-like growth factor 1Brain-derived neurotrophic factorglial cell-derived neurotrophic factortissue plasminogen activatorNational Institutes of Health stroke scaleModified Rankin scalesubventricular zoneMicroRNAMiRNANear-infraredMonocyte chemotactic protein-1green fluorescent protein
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Authors
Xinfeng Liu, Ruidong Ye, Tao Yan, Shan Ping Yu, Ling Wei, Gelin Xu, Xinying Fan, Yongjun Jiang, R. Anne Stetler, George Liu, Jieli Chen,