The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features

Article ID	Journal	Published Year	Pages	File Type
6286586	Progress in Neurobiology	2012	45 Pages	PDF

Abstract

âº Late-life depression is associated with cerebrovascular disease. âº The neurobiological profile is of fronto-subcortical dysfunction. âº Unique pathophysiologies likely underpin early-onset versus late-onset presentations. âº Early intervention must address risk factors for depression and cognitive decline.

Keywords

LLD DLPFC OFC FDG EOD DTI BOLD rCBF 5HTTLPR MRS RCT MTHFR HDL NaA fluorodeoxyglucose 5-HT ACC WMLs HMPAO PiB MTR ECT PFC BDNF N-acetyl aspartate Randomised controlled trial mild cognitive impairment Depression Early-onset depression Major depression Late-onset depression Late-life depression MRI Cho SPECT MEG Alzheimer's disease cardiovascular disease Late-onset diffusion tensor imaging Magnetic resonance imaging Neuroimaging functional magnetic resonance imaging fMRI single photon emission computed tomography Positron emission tomography Regional cerebral blood flow LOD یا Limit of detection Electroconvulsive therapy CNS CVD Serotonin blood oxygen level dependent central nervous system Cognitive White matter lesions magnetic resonance spectroscopy Vascular risk factors Brain-derived neurotrophic factor prefrontal cortex orbitofrontal cortex anterior cingulate cortex dorsolateral prefrontal cortex high density lipoprotein Cerebral metabolism Methylenetetrahydrofolate reductase Hypothalamic pituitary axis magnetoencephalography Selective serotonin reuptake inhibitor SSRI HPA myoinositol fractional anisotropy magnetization transfer ratio MCI PET Serotonin transporter gene Genetic creatine Choline