Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6286590 | Progress in Neurobiology | 2012 | 16 Pages |
Abstract
⺠The ubiquitin-proteasome system and autophagy are two main degradative pathways. ⺠Autophagy upregulation may protect against polyglutamine-expanded protein neurotoxicity. ⺠Autophagy compromise may occur in certain neurodegenerative diseases.
Keywords
mTORATGIP3SBMAIP3RIBSSCADRPLAGSK3βhttJnk1SNAREsInositol monophosphatasesoluble N-ethylmaleimide-sensitive factor attachment protein receptorsIMPasePI3KI1Rcyclic AMPcAMPinositol-1,4,5-triphosphateRNA interferenceRNAiROSspinocerebellar ataxiaAutophagyHuntington's diseasepolyglutamine diseasesNeurodegenerationubiquitin–proteasome systemendoplasmic reticulumphosphatidylethanolaminephosphatidylinositol-3-phosphatePhosphatidylinositol 3-kinaseInclusion bodiesHuntingtinmammalian target of rapamycinautophagy-related genesReactive oxygen speciesIP3 receptorsUPS
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Authors
Maria Jimenez-Sanchez, Frances Thomson, Eszter Zavodszky, David C. Rubinsztein,