Autophagy and polyglutamine diseases

Article ID	Journal	Published Year	Pages	File Type
6286590	Progress in Neurobiology	2012	16 Pages	PDF

Abstract

âº The ubiquitin-proteasome system and autophagy are two main degradative pathways. âº Autophagy upregulation may protect against polyglutamine-expanded protein neurotoxicity. âº Autophagy compromise may occur in certain neurodegenerative diseases.

Keywords

mTOR ATG IP3 SBMA IP3R IBS SCA DRPLA GSK3β htt Jnk1 SNAREs Inositol monophosphatase soluble N-ethylmaleimide-sensitive factor attachment protein receptors IMPase PI3K I1R cyclic AMP cAMP inositol-1,4,5-triphosphate RNA interference RNAi ROS spinocerebellar ataxia Autophagy Huntington's disease polyglutamine diseases Neurodegeneration ubiquitin–proteasome system endoplasmic reticulum phosphatidylethanolamine phosphatidylinositol-3-phosphate Phosphatidylinositol 3-kinase Inclusion bodies Huntingtin mammalian target of rapamycin autophagy-related genes Reactive oxygen species IP3 receptors UPS