| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6286595 | Progress in Neurobiology | 2012 | 10 Pages |
Abstract
⺠PGC-1α is a transcription co-activator that promotes mitochondrial function. ⺠Huntington's disease (HD) is characterized by abnormal bioenergetics. ⺠PGC-1α links mitochondrial dysfunction to transcription abnormalities in HD. ⺠Parkinson's disease may also result from PGC-1α dysfunction. ⺠PGC-1α is emerging a therapy target in neurodegenerative disease.
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Authors
Taiji Tsunemi, Albert R. La Spada,