Article ID Journal Published Year Pages File Type
6286600 Progress in Neurobiology 2012 15 Pages PDF
Abstract
► Intracellular antibody fragments (intrabodies) can be selected against toxic proteins. ► Intrabodies offer a targeted proteomic approach to polyglutamine toxicity. ► Phenotypic correction has been shown in Huntington's cell and animal models. ► Antibody engineering allows bifunctionality, and enhanced stability and efficacy. ► HD intrabody studies validate this technology for other neurodegenerative diseases.
Related Topics
Life Sciences Neuroscience Neuroscience (General)
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