| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6286600 | Progress in Neurobiology | 2012 | 15 Pages |
Abstract
⺠Intracellular antibody fragments (intrabodies) can be selected against toxic proteins. ⺠Intrabodies offer a targeted proteomic approach to polyglutamine toxicity. ⺠Phenotypic correction has been shown in Huntington's cell and animal models. ⺠Antibody engineering allows bifunctionality, and enhanced stability and efficacy. ⺠HD intrabody studies validate this technology for other neurodegenerative diseases.
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Neuroscience
Neuroscience (General)
Authors
David C. Butler, Julie A. McLear, Anne Messer,