Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis

Article ID	Journal	Published Year	Pages	File Type
6286607	Progress in Neurobiology	2011	16 Pages	PDF

Abstract

â¶ Autosomal dominant mutations in the presenilin gene cause familial Alzheimer's disease. â¶ Presenilins play an important role in neural progenitor cell maintenance and neurogenesis. â¶ Presenilin knockout and Alzheimer mouse models provide valuable information on the role of presenilin during nervous system development and in neurodegenerative disease. â¶ Zebrafish are emerging as an attractive vertebrate model organism to study presenilin and to identify novel therapeutic targets for Alzheimer's disease.

Keywords

PSEN AICD NSCs Dcx SGZ APP NTF RMS NICD SVZ CTF NPC Aβ hESC β-Amyloid FAD Alzheimer's disease Neurodegeneration rostral migratory stream APP intracellular domain Notch intracellular domain CNS doublecortin human embryonic stem cells neural progenitor cell Neural stem cells central nervous system dentate gyrus C-terminal fragment N-terminal fragment Zebrafish model Mouse model subgranular zone subventricular zone Neurogenesis Presenilin amyloid precursor protein