| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6286609 | Progress in Neurobiology | 2011 | 22 Pages |
Abstract
ⶠAdult neural stem cells are influenced by cellular and systemic energy metabolism. ⶠInsulin/IGF-1 signaling, AMPK, Sirt1, HIF, and ROS regulate NSC fate. ⶠDietary restriction and exercise enhance hippocampal neurogenesis. ⶠAging and pathologies with deregulated metabolism impact the NSC population.
Keywords
SVZbFGFmTORHDACOPCSIRTsirtuinIGF-1bHLHSGZSirt1HIFUCP2mTORC1PIP3Insulin/IGF-1mTORC2ASPMmTOR complex 2mitochondrial uncoupling protein 2AMPKNSCAICARACCHSCPI3KAMP-activated protein kinaseBDNFMAPKmTOR complex 1N-CoRNAD+ROSbasic helix-loop-helixforkhead Box OShhRedoxAgingHematopoietic stem cellNeural stem cellOligodendrocyte progenitor celldentate gyrussonic hedgehogHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)basic fibroblast growth factorinsulin-like growth factor 1Brain-derived neurotrophic factorFoxOphosphatase and tensin homologphosphatidylinositol (3,4,5)-triphosphatephosphoinositide 3-kinaseEnergy metabolismdietary restrictionBMPsubgranular zonesubventricular zoneNeurogenesisNAD, nicotinamide adenine dinucleotidemammalian target of rapamycinMammalian target of rapamycin (mTOR)histone deacetylaseHypoxiaretinoblastoma proteinBone morphogenetic proteinAMP-activated protein kinase (AMPK)mitogen-activated protein kinaseolfactory bulbPtenReactive oxidative speciesnuclear receptor co-repressor
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Authors
Victoria A. Rafalski, Anne Brunet,