| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6286613 | Progress in Neurobiology | 2011 | 27 Pages |
Abstract
ⶠDiscovery of olfactory receptor (OR) genes facilitated novel cellular assays used to deorphan ORs. ⶠThere is agreement on vertebrate olfactory signalling but debate surrounds signalling in insects. ⶠHere we review and compare the molecular mechanisms of olfaction in vertebrates and invertebrates. ⶠWe also summarise assay technologies applied to OR deorphanisation and biosensor research. ⶠProof-of-concept studies suggest that commercial olfactory biosensors will soon appear.
Keywords
GTPγSSAMcGMPEC50CVAFETEOGIP3GPCRinositol triphosphateMEAEAGSnMPFLIPROBPBAWPheromone receptorsGαGβCNGGFPGTPLAPSSWCNTelectrochemical impedence spectroscopycAMPG-protein coupled receptorGC–MSCyclic adenosine monophosphatemicroelectrode arraySAWSurface acoustic wavesFluorescence resonance energy transferbioluminescence resonance energy transferFRETEugenolBRETolfactionBioelectronic noseEISField-effect transistorSurface plasmon resonanceSPRGDPSelf-assembled monolayerOSNLight-addressable potentiometric sensorgas chromatography–mass spectrometryolfactory sensory neuronFLuorescence Imaging Plate ReaderBulk acoustic wavecyclic guanosine monophosphatequartz crystal microbalanceQCMSingle-walled carbon nanotubehalf maximal effective concentrationG-proteinguanine nucleotide binding proteingreen fluorescent proteinguanine triphosphateguanine diphosphateolfactory receptorOlfactory receptors
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Authors
Richard Glatz, Kelly Bailey-Hill,