Quantitative aspects of L-type Ca2+ currents

► L-type calcium currents play fundamental roles in neurons, cardiac cells and the immune system. ► They are often involved in pacemaker activity, control of firing rates, gene expression and pathological states. ► Modeling of these currents may include voltage- and calcium-dependent processes. ► Extensive tables of the properties of L-type channels including subtypes are given. ► There is a need for experimental data on the properties of L-type channels in native cells at physiological calcium levels.