| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6286626 | Progress in Neurobiology | 2012 | 14 Pages |
Abstract
⺠Methylene blue has unique antioxidant and metabolic-enhancing hormetic properties. ⺠Low-dose methylene blue improves memory retention by enhancing consolidation. ⺠Memory-improving effects of methylene blue are mediated by cytochrome oxidase. ⺠Methylene blue local brain effects on mitochondria function are activity-dependent. ⺠Low-dose methylene blue prevents neurodegeneration induced by metabolic insults.
Keywords
methylthioninium chlorideGCLMMANOSFADH2NADPHUSPflavin adenine dinucleotidePCCAdenosine TriphosphateATPpost-traumatic stress disorderPTSDmild cognitive impairmentUnited States PharmacopeiaAlzheimer's diseaseMemorycytochrome oxidaseposterior cingulate cortexganglion cell layerMethylmalonateMethylene blueNeuroprotectionMitochondriaNADHNitric oxidenitric oxide synthasenicotine adenine dinucleotidenicotine adenine dinucleotide phosphateMCI
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Authors
Julio C. Rojas, Aleksandra K. Bruchey, F. Gonzalez-Lima,