Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Article ID	Journal	Published Year	Pages	File Type
6286629	Progress in Neurobiology	2012	9 Pages	PDF

Abstract

âº p62 interacts with several proteins to regulate cellular signaling, protein trafficking, aggregation and degradation. âº p62 regulates the degradation of tau protein and aggregation to fibrils in Alzheimer's disease and other tauopathies. âº Lack of p62 protein provokes tau pathology in neurons. âº Decline in the level of cytoplasmic p62 protein in Alzheimer's disease can disturb signaling pathways.

Keywords

TLR PB1 APP AMPA RIP1 PSEN1 NGF PU.1 aPKC SH2 NMDA PINK1 MAP kinase kinase kinase ZIP CREB α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor ATG PKC MAP kinase kinase GluR LC3 TRAF6 Kir p62 Presenilin-1 NLS GSK-3 8-OHdG TNF nES Jnk C-terminus of Hsc70 interacting protein IL-1 Nbr1 MYD88 NF-κB Pea3 Nrf2 E-twenty six sequestosome TBS MEKK3 VDAC1 ubiquitin-associated ERK UBA PML ETs 8-Hydroxy-2-deoxyguanosine BDNF keap1 C/EBP c-Jun N-terminal kinase MAPK PTEN-induced putative kinase 1 Pest Alzheimer Akt Autophagy interleukin-1 LIR Alzheimer's disease Trk long-term potentiation LTP Toll-like receptor Tau zinc finger domain Rank Aging nuclear export signal nuclear localization signal tumor necrosis factor receptor-associated factor 6 nerve growth factor Brain-derived neurotrophic factor tumor necrosis factor nuclear factor (erythroid-derived 2)-like 2 nuclear factor-κB MEK autophagy-related LC3-interacting region Src Homology 2 myeloid differentiation primary response gene 88 CCAAT-enhancer binding protein receptor-interacting protein 1 Kelch-like ECH-associated protein 1 atypical protein kinase C amyloid-β precursor protein protein kinase B Protein kinase C mitogen-activated protein kinase CHiP extracellular signal-regulated kinase glycogen synthase kinase-3 N-methyl-d-aspartate receptor Glutamate receptor receptor activator of NF-κB