Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6287170 | Hearing Research | 2015 | 15 Pages |
Abstract
We also examine the pathology of the spiral ganglion after chronic, long-term hair cell damage. Remarkably, there is little or no neuronal loss following the ototoxic insult, even at 8 months post-damage. This is similar to the situation often seen in the human, where functioning neurons can persist even decades after hair cell loss, contrasting with the rapid, secondary degeneration found in rats, mice and other small mammals. We propose that the combination of these factors makes the gerbil a good model for ototoxic damage by induced hair cell loss.
Keywords
PBSMBPOHCDAPIPFASGNABR4,6-diamidino-2-phenylindoleBSARWM bovine serum albuminEDTAEthylenediaminetetraacetic acidIHCanalysis of varianceANOVAOuter hair cellsinner hair cellsRound Window MembranePhosphate buffered salinespiral ganglion neuronparaformaldehydeauditory brainstem responseMyelin basic protein
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Authors
Leila Abbas, Marcelo N. Rivolta,