| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6287554 | Hearing Research | 2013 | 8 Pages |
Abstract
⺠Mitochondria play a major role in cochlear function and dysfunction. ⺠Noise may affect mitochondrial metabolism by calcium influx. âºÂ Presbycusis correlates with distinct mitochondrial lesions but not necessarily with oxidative stress. ⺠Aminoglycosides inhibit the respiratory chain via targeting mitochondrial function. ⺠Non-ototoxic aminoglycosides can be developed by eliminating their activity against the mitochondrial ribosome.
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Authors
Erik C. Böttger, Jochen Schacht,