| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6287605 | Hearing Research | 2012 | 12 Pages |
Abstract
⺠cAMP exerts a biphasic effect on SGN neurite length. ⺠The effect of cAMP on SGN neurite length is not substrate dependent. ⺠PKA activity in the cytoplasm and in the nucleus inhibits SGN neurite length. ⺠PI3-K signaling partially rescues neurite length in SGNs with elevated PKA activity. ⺠PKA does not contribute to the inhibition of neurite length by depolarization.
Keywords
CaMKPKIEpacNLSNT-3forskolinPI3-Kneurofilament 200NF200SGNpKaMAGFskGFPnESJnkBDNFc-Jun N-terminal kinasecAMPDMSOanalysis of varianceANOVAstandard error of the meanDimethyl sulfoxidenuclear export signalbrain derived neurotrophic factorPhosphatidylinositol 3-kinaseSEMneurotrophin-3spiral ganglion neurongreen fluorescent proteinprotein kinase ACa2+/calmodulin-dependent protein kinasemitogen-activated protein kinase kinaseMyelin associated glycoprotein
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Authors
Ningyong Xu, Jonathan Engbers, Sobia Khaja, Linjing Xu, J. Jason Clark, Marlan R. Hansen,