| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6287609 | Hearing Research | 2012 | 9 Pages |
Abstract
⺠We investigated auditory effects of Cdh23 variants in both C57BL/6J and CBA/CaJ genetic backgrounds. ⺠The CBA/CaJ-derived Cdh23 allele lessens hearing loss and decreases hair cell loss in a C57BL/6J genetic background. ⺠The C57BL/6J-derived Cdh23 allele has no effect on hearing loss or hair cell death in a CBA/CaJ genetic background. ⺠Deleterious alleles at other loci in addition to Cdh23 must contribute to the accelerated hearing loss of C57BL/6J mice. ⺠Mice of the C57BL/6J and C57BL/6N substrains have identical hearing loss profiles.
Keywords
Related Topics
Life Sciences
Neuroscience
Sensory Systems
Authors
Kelly L. Kane, Chantal M. Longo-Guess, Leona H. Gagnon, Dalian Ding, Richard J. Salvi, Kenneth R. Johnson,