Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6288203 | Research in Microbiology | 2008 | 7 Pages |
Abstract
Bacteria use a variety of mechanisms for intercellular communication. Here we show that deletion of the uup gene, which encodes a soluble ATP binding cassette (ABC) ATPase, renders the mutant strain sensitive to its parent when they are grown together in the same medium. Our data suggest that the decrease in viability of the mutant is dependent on direct cell-to-cell contact with the parent strain. Furthermore, we show that the presence of intact Walker B motifs in Uup is required for immunity or resistance to the parental strain, suggesting that ATP hydrolysis is an important determinant of this phenotype.
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Authors
Dorothée Murat, Laurent Goncalves, Elie Dassa,