Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation

- H. polygyrus ES (HES) suppresses alum-induced type 2 responses in MyD88xTRIF doubly-deficient mice.
- HES does not require the presence of B cells to block alum-induced type 2 responses.
- Regulatory T cell depletion does not reverse suppression of alum-induced type 2 responses by HES.
- HES-administered mice show significant inhibition of type 2 innate lymphoid cell activation.