Development of novel valerolactam-benzimidazole hybrids anthelmintic derivatives: Diffusion and biotransformation studies in helminth parasites

- Further studies of novel benzimidazole bioactive hybrids are presented.
- Diffusion in H. contortus (susceptible/from sheep farms) and M. vogae is presented.
- Sulphoxidation drug metabolism was measured in both target parasites.
- Oxidation was more relevant in H. contortus parasites from sheep farms.
- New hybrid compound 10 was not oxidized and showed a high diffusion rate.