| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6290758 | Experimental Parasitology | 2015 | 12 Pages |
Abstract
- Schistosoma mansoni appears to cleave CD23 to release a 15âkDa soluble (s) CD23 fragment (SG-sCD23).
- SG-sCD23 can prevent IgE from binding to its receptors and prevent acute allergy.
- A point mutation in the IgE-binding head, D258E, increased efficacy of SG-sCD23.
- SG-sCD23 may be an effective allergy treatment.
- Immunity to calpain may inhibit CD23 cleavage and improve protection against schistosomiasis.
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Authors
Qyana Griffith, YanMei Liang, Patrick Whitworth, Carlos Rodriguez-Russo, Ahmad Gul, Afzal A. Siddiqui, John Connor, Pauline Mwinzi, Lisa Ganley-Leal,