Toxoplasma gondii isolate with genotype Chinese 1 triggers trophoblast apoptosis through oxidative stress and mitochondrial dysfunction in mice

- Maternal infection with Wh3 Toxoplasma gondii induces trophoblast apoptosis.
- Wh3 strain promotes ROS production and peroxidation damage to placental tissues.
- Generation of ROS in Wh3 strain infection is mainly through NADPH oxidase.
- Wh3 infection contributes to oxidative stress-induced mitochondrial dysfunction.