| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6291076 | Experimental Parasitology | 2013 | 12 Pages |
Abstract
- Plexaura homomalla extract inhibits Cruzipain and Falcipain 2 in the nanomolar range.
- An inhibitor-enriched fraction is active against cysteine(CP) and aspartyl proteases.
- CP inhibitors represent >90% of total inhibitory activity in enriched fraction.
- Inhibitor-enriched fraction reduces infection and replication of Trypanosoma cruzi.
- Inhibitor-enriched fraction also inhibits the replication of Plasmodium falciparum.
Keywords
CMDACNTFAsodium acetate bufferAmCAAFPBAPAE-64NaAc7-amino-4-methyl coumarinAcetonitrileTrifluoracetic acidtrans-Epoxysuccinyl-l-leucylamido-(4-guanidino)butaneTrypanosoma cruziRoom temperatureantiparasitic agentsReverse-phaseTight-binding inhibitorabsorbance unitsPlasmodium falciparumCysteine peptidasescarboxymethyl dextran
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Emir Salas-Sarduy, Aymara Cabrera-Muñoz, Ana Cauerhff, Yamile González-González, Sebastián A. Trejo, Agustina Chidichimo, Maria de los Angeles Chávez-Planes, Juan José Cazzulo,