| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6291227 | Experimental Parasitology | 2013 | 10 Pages |
Abstract
⺠T. gondii infection eliminated the staurosporine-triggered mitochondrial apoptotic events. ⺠T. gondii infection in vitro and in vivo induced the phosphorylation of PKB/Akt and Bcl-2-associated death promoter (Bad). ⺠PI 3-kinase inhibitors reduced phosphorylation of Bad in a dose-dependent manner and failed to inhibit Bax translocation. ⺠These data suggest that anti-apoptosis by T. gondii occurs partly through phosphorylative inactivation of Bad.
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Authors
Juan-Hua Quan, Guang-Ho Cha, Wei Zhou, Jia-Qi Chu, Yoshifumi Nishikawa, Young-Ha Lee,