| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6291672 | Experimental Parasitology | 2011 | 4 Pages |
Abstract
⺠Nematode polyprotein allergens (NPAs) are immunodominant antigens of parasitic nematodes. ⺠The atomic structure of the NPA of Ascaris, ABA-1A, has been solved. ⺠ABA-1A has a compact helical structure with a 3-D architecture of a kind not previously known. ⺠ABA-1A has two subdomains, each with a hydrophobic binding pocket for small lipid molecules. ⺠The structure confirms that the fundamental unit of NPAs arose from an ancient duplication event.
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Authors
Malcolm W. Kennedy,