| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6291682 | Experimental Parasitology | 2011 | 8 Pages |
Abstract
⺠ABC systems impact heath and illness by mediating multidrug resistance (MDR) via overexpression. ⺠ABC systems that confer MDR are found in subfamilies A, B, C, and G; in nematodes they are in subfamily B. ⺠Following moxidectin treatment there was overexpression of ABC systems in subfamilies A, B, C, and G. ⺠Inhibition of ABC systems potentiated sensitivity of females and microfilariae to moxidectin. ⺠ABC systems in Brugia malayi influence sensitivity to moxidectin and may affect drug resistance.
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Authors
L.E. Stitt, J.B. Tompkins, L.A. Dooley, B.F. Ardelli,