| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6292086 | Experimental Parasitology | 2011 | 10 Pages |
Abstract
⺠A 336 bp ORF of ribosomal P1 of Leishmania donovani used as protein or DNA vaccine in hamster model. ⺠Protein vaccine failed to cause any protection, showed high IL-10 and IFNγ but low IL-12. ⺠Double dose immunization with DNA vaccine resisted the increase in spleen parasite burden by 75.68%. ⺠DNA Vaccine induced a Th-1 type of cytokine profile with high IL-12, IFNγ and low IL-10. ⺠DNA vaccine shows potential as a vaccine candidate.
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Authors
Shet Masih, Sunil K. Arora, Rakesh K. Vasishta,