Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1

Article ID	Journal	Published Year	Pages	File Type
6292296	Experimental Parasitology	2011	7 Pages	PDF

Abstract

âº The glycosylphosphatidylinositol (GPI) anchors of malaria parasite, Plasmodium falciparum, activate macrophages through TLR2-mediated signaling, leading to MAPK and NF-ÎºB activation and downstream cytokine production. âº The P. falciparum GPIs are preferentially recognized by TLR2-TLR1 dimer rather than TLR2-TLR6 dimer. âº The selective recognition of P. falciparum GPIs by TLR2-TLR1 is analogous to that of bacterial triacylated lipoproteins or synthetic triacylated peptides.

Keywords

PAMP TLR GPi BMDM Glycosylphosphatidylinositol anchors pathogen-associated molecular pattern Toll-like receptor Recognition specificity bone marrow derived macrophages Plasmodium falciparum glycosylphosphatidylinositol Toll-like receptors