Article ID Journal Published Year Pages File Type
6292333 Experimental Parasitology 2011 7 Pages PDF
Abstract
► (2E)-1-(7-fluoro-3-methyl-quinoxalin-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propenone is selectively active against proliferative cells (cancer and Leishmania) and inactive against murine peritoneal macrophages. ► (2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-quinoxalin-2-yl)-propenone is selectively active against Leishmania and inactive against the other proliferative cells. ► in silico studies show that these compounds could interact with the poly (ADP-ribose) polymerase protein of Trypanosoma cruzi.
Related Topics
Life Sciences Immunology and Microbiology Parasitology
Authors
, , , , , , , , , , , ,