Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6292333 | Experimental Parasitology | 2011 | 7 Pages |
Abstract
⺠(2E)-1-(7-fluoro-3-methyl-quinoxalin-2-yl)-3-(3,4,5-trimethoxy-phenyl)-propenone is selectively active against proliferative cells (cancer and Leishmania) and inactive against murine peritoneal macrophages. ⺠(2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-quinoxalin-2-yl)-propenone is selectively active against Leishmania and inactive against the other proliferative cells. ⺠in silico studies show that these compounds could interact with the poly (ADP-ribose) polymerase protein of Trypanosoma cruzi.
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Authors
Yannick Estevez, Miguel Quiliano, Asunción Burguete, Billy Cabanillas, Mirko Zimic, Edith Málaga, Manuela Verástegui, Silvia Pérez-Silanes, Ignacio Aldana, Antonio Monge, Denis Castillo, Eric Deharo,